This Foundational course will provide participants with practice and evidence-based approaches to identifying, engaging and managing co-existing physical and mental health needs. Participants will develop an integrated approach to care for these patient issues and will obtain access to practice-ready toolkits to implement in their setting.

Course Objectives

• Identify the prevalence and impact of mental health conditions on physical health outcomes
• Describe and use evidence-based assessment tools to improve identification of mental health needs in patients with physical health issues
• Describe and perform an integrated case formation to address co-occurring physical and mental health needs

Accreditation

• This program has been accredited by the College of Family Physicians of Canada for up to 7 Mainpro+ credits.

Duration: September 18 to October 29, 2023

Fee: $275.00

Topic: Platelets from 13-lined Ground Squirrels are Resistant to Cold Storage Lesion

Presented by:

Dr. Scott Cooper
Professor of Biology at the University of Wisconsin-LaCrosse

Abstract: Hibernating ground squirrels have dramatically decreased heart rates (3-5 beats per minute) and blood flow, which should put them at risk of forming blood clots. In response, they have several adaptations during hibernation that prevent blood clotting, including 3-fold decreases in Factors VIII (FVIII) and IX (FIX), and 10-fold decreases in von Willebrand factor (vWF), neutrophils, and platelets. Ground squirrel platelets are resistant to in vivo and in vitro cold storage lesions and are not rapidly cleared after transfusion. This could be due to a combination of altered signaling pathways, resistance to cold-induced cellular damage, and interactions with extracellular factors. This research is pioneering the use proteomic and metabolomic techniques to determine how ground squirrel platelets are resistant to cold storage lesions in platelets and could lead to medical advances to treat thrombocytopenia, store human platelets in the cold for transfusions, and regulate blood coagulation in cases of accidental or induced hypothermia.

Date: January 11, 2023 @ 1:00PM - 2:00PM PT

Duration: 1 hour

The recording for this CBR event is now available.

Topic: Novel Roles of Platelets in Infection and Inflammation

Presented by

Dr. Robert A. Campbell
Associate Professor of Medicine at the University of Utah

Abstract:

I have concentrated my research effort on dissecting the mechanisms underpinning how cells alter coagulation under normal and disease situations, as well as determining how hemostasis and thrombosis, in turns, alters cellular response during inflammation. In particular, I have focused on understanding the regulation of transcription and translation in megakaryocyte and platelets under health and disease. To accomplish these goals, I have developed in vitro and in vivo model systems to examine gene and protein expression in megakaryocytes and platelets. We have elucidated novel mechanisms regulating megakaryocyte and platelet function and activation under normal homeostasis, including translational control mechanism regulated by microRNAs. We have also discovered that platelets and megakaryocytes possess novel intrinsic host defense mechanisms in addition to their ability to respond to inflammatory signals that induce robust changes in gene and protein expression. We have also demonstrated these changes in gene expression alter thrombo‐inflammatory responses, which often occur in the setting of aging and in the context of stroke. We also have extensively studied platelet interactions with other cells including neutrophils and monocytes and how these interactions alter platelet and leukocyte responses. In addition, my laboratory has significant experience dissecting molecular pathway in platelets, which regulate thrombosis using murine model systems. This includes in vivo models of thrombosis such as venous thrombosis, pulmonary embolism, and ischemic stroke. In these studies, we have used state‐of‐the‐art technologies including RNA‐seq to examine the transcriptional changes in platelets and megakaryocytes from mice to uncover novel genes critical for platelet responses during inflammation and thrombosis.

Date: January 18, 2023 @ 1:00PM - 2:00PM PT

Duration: 1 hour

The recording for this CBR event is now available.

Topic: Who is missing? Underrepresented communities in trauma research.

Presented by

Dr. Barbara Haas, MD, PhD, FRCSC
Assistant Professor, Department of Surgery, University of Toronto

Learning Objectives

1. To review the relationship between sex and trauma outcomes
2. To review the link between age and trauma outcomes
3. To review the link between marginalization and trauma outcomes

Accreditation

The University of Toronto Transfusion Medicine Rounds is a self-approved group learning activity (Section1) as defined by the Maintenance of Certification program of the Royal College of Physicians and Surgeons of Canada.

Date: January 26, 2023 @ 12:00PM - 1:00PM EST

Duration: 1 hour

The recording for this ORBCoN event is now available.